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Issue 14, 2013
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Highly luminescent water-soluble quaternary Zn–Ag–In–S quantum dots for tumor cell-targeted imaging

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Abstract

Exploring the synthesis and biomedical applications of biocompatible quantum dots (QDs) is currently one of the fastest growing fields of nanotechnology. Hence, in this work, we present a facile approach to produce water-soluble (cadmium-free) quaternary Zn–Ag–In–S (ZAIS) QDs. Their efficient photoluminescence (PL) emissions can be tuned widely in the range of 525–625 nm by controlling the size and composition of the QDs with the PL quantum yields (QYs) of 15–30%. These highly luminescent ZAIS QDs are less toxic due to the absence of highly toxic cadmium, and can be versatilely modified by a DHLA-PEG-based ligand. Importantly, after being modified by tumor cell-specific targeting ligands (e.g., folate and RGD peptide), the PEGylated quaternary QDs show potential applications in tumor cell imaging as a promising alternative for Cd-based QDs.

Graphical abstract: Highly luminescent water-soluble quaternary Zn–Ag–In–S quantum dots for tumor cell-targeted imaging

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Publication details

The article was received on 07 Jan 2013, accepted on 30 Jan 2013 and first published on 30 Jan 2013


Article type: Paper
DOI: 10.1039/C3CP00046J
Citation: Phys. Chem. Chem. Phys., 2013,15, 5078-5083
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    Highly luminescent water-soluble quaternary Zn–Ag–In–S quantum dots for tumor cell-targeted imaging

    D. Deng, J. Cao, L. Qu, S. Achilefu and Y. Gu, Phys. Chem. Chem. Phys., 2013, 15, 5078
    DOI: 10.1039/C3CP00046J

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