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Issue 25, 2013
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Characterisation of organic solid forms and real-time in situ monitoring of their transformations using solid-state fluorescence

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Abstract

We demonstrate the application of solid-state fluorescence spectroscopy for the real-time monitoring and characterisation of solid forms (e.g. polymorphs, solvates, cocrystals) of pharmaceutical molecules. This proof-of-principle study focuses on the pharmaceutical indomethacin which, although poorly fluorescent in solution, in the solid state yields highly fluorescent amorphous, polymorphic, solvate and cocrystal forms. We show that solid forms of indomethacin can be readily distinguished by their fluorescent properties and, by using a simple and readily available experimental set-up, we reveal that fluorescence spectroscopy can be used to quantify amorphous and crystalline forms in a mixture and to monitor the kinetics of their interconversion in situ and in real-time (30 seconds resolution or less).

Graphical abstract: Characterisation of organic solid forms and real-time in situ monitoring of their transformations using solid-state fluorescence

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Publication details

The article was received on 07 Apr 2013, accepted on 03 May 2013 and first published on 09 May 2013


Article type: Paper
DOI: 10.1039/C3CE40604K
Citation: CrystEngComm, 2013,15, 5100-5106
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    Characterisation of organic solid forms and real-time in situ monitoring of their transformations using solid-state fluorescence

    M. Frenette, G. Cosa and T. Friščić, CrystEngComm, 2013, 15, 5100
    DOI: 10.1039/C3CE40604K

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