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Issue 18, 2013
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Microwave assisted synthesis of caffeine/maleic acid co-crystals: the role of the dielectric and physicochemical properties of the solvent

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Abstract

In the present work microwave radiation has been used to prepare the 1 : 1 and 2 : 1 co-crystals of caffeine and maleic acid. We obtained 1 : 1 co-crystals in the presence of water and methanol and we also see Form II of the 1 : 1 co-crystal in methanol. Co-crystallisation under microwave irradiation is shown to be controlled by the saturation of solvent at the reacting interface between the co-crystal components as well as the solvent dielectric properties.

Graphical abstract: Microwave assisted synthesis of caffeine/maleic acid co-crystals: the role of the dielectric and physicochemical properties of the solvent

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Publication details

The article was received on 07 Dec 2012, accepted on 26 Feb 2013 and first published on 26 Feb 2013


Article type: Paper
DOI: 10.1039/C3CE40292D
Citation: CrystEngComm, 2013,15, 3705-3710
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    Microwave assisted synthesis of caffeine/maleic acid co-crystals: the role of the dielectric and physicochemical properties of the solvent

    S. Pagire, S. Korde, R. Ambardekar, S. Deshmukh, R. C. Dash, R. Dhumal and A. Paradkar, CrystEngComm, 2013, 15, 3705
    DOI: 10.1039/C3CE40292D

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