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Issue 11, 2013
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Solution mediated phase transformations between co-crystals

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Abstract

A solution mediated transformation between two co-crystal phases has been observed for the p-toluensulfonamide–triphenylphosphine oxide co-crystal system. This system has two known co-crystals with 1 : 1 and 3 : 2 stoichiometry respectively, and the ternary phase diagram (TPD) for the system has been determined in acetonitrile previously. By manipulating the solution composition in this solvent to a region of the TPD where the 1 : 1 co-crystal is stable, the 3 : 2 co-crystal could be observed to convert to the 1 : 1 co-crystal. The corresponding transformation was true for the 1 : 1 co-crystal in a region of the TPD where the 3 : 2 co-crystal is stable; the 1 : 1 co-crystal converted to the 3 : 2 co-crystal.

Graphical abstract: Solution mediated phase transformations between co-crystals

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Publication details

The article was received on 02 Nov 2012, accepted on 14 Dec 2012 and first published on 07 Jan 2013


Article type: Communication
DOI: 10.1039/C2CE26801A
Citation: CrystEngComm, 2013,15, 2044-2047
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    Solution mediated phase transformations between co-crystals

    D. M. Croker, R. J. Davey, Å. C. Rasmuson and C. C. Seaton, CrystEngComm, 2013, 15, 2044
    DOI: 10.1039/C2CE26801A

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