Issue 91, 2013
From the journal:

Chemical Communications

Assembly of catalase-based bioconjugates for enhanced anticancer efficiency of photodynamic therapy in vitro†

Jie Zhao,a   Jinbo Fei,a   Cuiling Du,a   Wei Cui,a   Hongchao Maa  and  Junbai Li*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Lab of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
E-mail: jbli@iccas.ac.cn
Fax: +86-10-82612629
Tel: +86-10-82614087

Abstract

An oxygen generation core–shell structure uploading rose bengal has been fabricated by covalent assembly of catalase and alginate dialdehyde via Schiff's base. The composite can catalyze the decomposition of intracellular H2O2 to increase the concentration of O2, which effectively enhances the anticancer efficiency of photodynamic therapy in vitro.

Graphical abstract: Assembly of catalase-based bioconjugates for enhanced anticancer efficiency of photodynamic therapy in vitro

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Article information

DOI
https://doi.org/10.1039/C3CC46969G
Article type
Communication
Submitted
12 Sep 2013
Accepted
25 Sep 2013
First published
26 Sep 2013

Chem. Commun., 2013,49, 10733-10735

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Assembly of catalase-based bioconjugates for enhanced anticancer efficiency of photodynamic therapy in vitro

J. Zhao, J. Fei, C. Du, W. Cui, H. Ma and J. Li, Chem. Commun., 2013, 49, 10733 DOI: 10.1039/C3CC46969G

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