Expanding dynamic kinetic protocols: transaminase-catalyzed synthesis of α-substituted β-amino ester derivatives

Aníbal Cuetos; Iván Lavandera; Vicente Gotor

doi:10.1039/C3CC46760K

Expanding dynamic kinetic protocols: transaminase-catalyzed synthesis of α-substituted β-amino ester derivatives

Aníbal Cuetos,^a Iván Lavandera*^a and Vicente Gotor*^a

* Corresponding authors

^a Dpto. de Química Orgánica e Inorgánica, Universidad de Oviedo. c/Julián Clavería 8, Oviedo, Spain
E-mail: lavanderaivan@uniovi.es, vgs@uniovi.es
Fax: +34 985 103448
Tel: +34 985 103452

Abstract

Several α-alkylated β-amino esters have been obtained via DKR processes employing a kit of transaminases and isopropylamine as an amino donor in aqueous medium under mild conditions. Thus, while acyclic α-alkyl-β-keto esters afforded excellent conversions and enantioselectivities, although usually low diastereoselectivities, using more constrained cyclic β-keto esters high to excellent inductions were obtained.

Supplementary files

Publication details

The article was received on 04 Sep 2013, accepted on 25 Sep 2013 and first published on 27 Sep 2013

Article type: Communication

DOI: 10.1039/C3CC46760K

Citation: Chem. Commun., 2013,49, 10688-10690

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Expanding dynamic kinetic protocols: transaminase-catalyzed synthesis of α-substituted β-amino ester derivatives

A. Cuetos, I. Lavandera and V. Gotor, Chem. Commun., 2013, 49, 10688
DOI: 10.1039/C3CC46760K
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Chemical Communications

Expanding dynamic kinetic protocols: transaminase-catalyzed synthesis of α-substituted β-amino ester derivatives

Abstract

Supplementary files

Publication details

Expanding dynamic kinetic protocols: transaminase-catalyzed synthesis of α-substituted β-amino ester derivatives

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