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Issue 85, 2013
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2,4-Diamino-6,7-dimethylpteridine as a fluorescent ligand for binding and sensing an orphan cytosine in RNA duplexes

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Abstract

We report on a new fluorescent ligand, 2,4-diamino-6,7-dimethylpteridine, that can strongly and selectively bind to an orphan cytosine opposite an abasic site in RNA duplexes. We describe a significant effect of the substituents attached to the pteridine ring on the binding behavior in comparison with a structurally-similar pteridine derivative.

Graphical abstract: 2,4-Diamino-6,7-dimethylpteridine as a fluorescent ligand for binding and sensing an orphan cytosine in RNA duplexes

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Publication details

The article was received on 09 Aug 2013, accepted on 05 Sep 2013 and first published on 05 Sep 2013


Article type: Communication
DOI: 10.1039/C3CC46085A
Citation: Chem. Commun., 2013,49, 9983-9985
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    2,4-Diamino-6,7-dimethylpteridine as a fluorescent ligand for binding and sensing an orphan cytosine in RNA duplexes

    Y. Sato, Y. Toriyabe, S. Nishizawa and N. Teramae, Chem. Commun., 2013, 49, 9983
    DOI: 10.1039/C3CC46085A

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