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Issue 87, 2013
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Recent efforts to construct the B-ring of bryostatins

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Abstract

Among macrocyclic natural products, bryostatins have excellent bioactivities and unique structures that make them highly attractive to synthetic chemists. Particularly challenging for the total synthesis of bryostatins is the B-ring, which features a cis-tetrahydropyran containing a geometrically defined exocyclic Z-methyl enoate. Synthetic chemists have recently displayed great prowess in their efforts to construct this ring, and here we summarize the progress towards this goal.

Graphical abstract: Recent efforts to construct the B-ring of bryostatins

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Publication details

The article was received on 04 Aug 2013, accepted on 03 Sep 2013 and first published on 03 Sep 2013


Article type: Feature Article
DOI: 10.1039/C3CC45947K
Citation: Chem. Commun., 2013,49, 10211-10220
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    Recent efforts to construct the B-ring of bryostatins

    L. Gao, J. Lu and Z. Song, Chem. Commun., 2013, 49, 10211
    DOI: 10.1039/C3CC45947K

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