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Issue 85, 2013
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A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(II) complex as potential hR2 RNR inhibitors

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Abstract

A new paullone–TEMPO conjugate and its copper(II) complex inhibit RNR activity and show high antiproliferative activity in human cancer cell lines.

Graphical abstract: A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(ii) complex as potential hR2 RNR inhibitors

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Publication details

The article was received on 27 Jul 2013, accepted on 03 Sep 2013 and first published on 03 Sep 2013


Article type: Communication
DOI: 10.1039/C3CC45743E
Citation: Chem. Commun., 2013,49, 10007-10009
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    A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(II) complex as potential hR2 RNR inhibitors

    A. Dobrov, S. Göschl, M. A. Jakupec, A. Popović-Bijelić, A. Gräslund, P. Rapta and V. B. Arion, Chem. Commun., 2013, 49, 10007
    DOI: 10.1039/C3CC45743E

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