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Issue 88, 2013
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Efficient asymmetric synthesis of lamivudine via enzymatic dynamic kinetic resolution

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Abstract

The anti-HIV nucleoside lamivudine was asymmetrically synthesized in only three steps via a novel surfactant-treated subtilisin Carlsberg-catalyzed dynamic kinetic resolution protocol. The enantiomer of lamivudine could also be accessed using the same protocol catalyzed by Candida antarctica lipase B.

Graphical abstract: Efficient asymmetric synthesis of lamivudine via enzymatic dynamic kinetic resolution

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Publication details

The article was received on 22 Jul 2013, accepted on 09 Sep 2013 and first published on 10 Sep 2013


Article type: Communication
DOI: 10.1039/C3CC45551C
Citation: Chem. Commun., 2013,49, 10376-10378
  • Open access: Creative Commons BY-NC license
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    Efficient asymmetric synthesis of lamivudine via enzymatic dynamic kinetic resolution

    L. Hu, F. Schaufelberger, Y. Zhang and O. Ramström, Chem. Commun., 2013, 49, 10376
    DOI: 10.1039/C3CC45551C

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