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Issue 77, 2013
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Highly regioselective synthesis of 2,4,5-(hetero)aryl substituted oxazoles by intermolecular [3+2]-cycloaddition of unsymmetrical internal alkynes

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Abstract

A robust N-nucleophilic 1,3-N,O-dipole equivalent reacts with unsymmetrical internal alkynes under gold catalysis. Conjugation from a remote nitrogen lone pair enables and controls this convergent and highly regioselective process.

Graphical abstract: Highly regioselective synthesis of 2,4,5-(hetero)aryl substituted oxazoles by intermolecular [3+2]-cycloaddition of unsymmetrical internal alkynes

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Publication details

The article was received on 17 Jul 2013, accepted on 08 Aug 2013 and first published on 08 Aug 2013


Article type: Communication
DOI: 10.1039/C3CC45410J
Citation: Chem. Commun., 2013,49, 8617-8619
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    Highly regioselective synthesis of 2,4,5-(hetero)aryl substituted oxazoles by intermolecular [3+2]-cycloaddition of unsymmetrical internal alkynes

    E. Chatzopoulou and P. W. Davies, Chem. Commun., 2013, 49, 8617
    DOI: 10.1039/C3CC45410J

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