Synthesis, spectroscopic and biological studies of a fluorescent Pt(ii) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent†
Abstract
The bi-functional complex [PtII(terpy)(py-naphth)](NO3)2(1), incorporating both 2,2′:6′,2′′-terpyridine and 4-N,N′-dimethylamino-1,8-naphthalimide moieties, displays a high binding affinity for DNA as well as displaying cytotoxicity towards and inducing apoptosis in malignant cell lines.