Issue 74, 2013
From the journal:

Chemical Communications

Catalytic stereospecific alkylation of malononitriles with enantioenriched primary allylic amines†

Man-Bo Li,a   Hao Li,a   Ju Wang,a   Cong-Rong Liua  and  Shi-Kai Tian*ab  

* Corresponding authors

a Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China
E-mail: tiansk@ustc.edu.cn
Fax: +86 551-6360-1592
Tel: +86 551-6360-0871

b Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

Abstract

An unprecedented alkylation reaction of malononitriles with enantioenriched primary allylic amines has been developed in a stereospecific manner through palladium-catalyzed sp3 C–N bond cleavage without additives at room temperature.

Graphical abstract: Catalytic stereospecific alkylation of malononitriles with enantioenriched primary allylic amines

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Article information

DOI
https://doi.org/10.1039/C3CC44914A
Article type
Communication
Submitted
01 Jul 2013
Accepted
23 Jul 2013
First published
24 Jul 2013

Chem. Commun., 2013,49, 8190-8192

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Catalytic stereospecific alkylation of malononitriles with enantioenriched primary allylic amines

M. Li, H. Li, J. Wang, C. Liu and S. Tian, Chem. Commun., 2013, 49, 8190 DOI: 10.1039/C3CC44914A

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