Issue 83, 2013

A chemical genomics approach to identification of interactions between bioactive molecules and alternative reading frame proteins

Abstract

Magic TagĀ® immobilisation of bioactive molecules coupled with bacteriophage display, followed by an ELISA assay, provides a protocol that can probe interactions of drugs with putative products of alternative initiation of translation as exemplified by the binding of immobilised flecainide to protein products of genes linked to sudden cardiac death.

Graphical abstract: A chemical genomics approach to identification of interactions between bioactive molecules and alternative reading frame proteins

Supplementary files

Article information

Article type
Communication
Submitted
20 Jun 2013
Accepted
30 Aug 2013
First published
02 Sep 2013

Chem. Commun., 2013,49, 9588-9590

A chemical genomics approach to identification of interactions between bioactive molecules and alternative reading frame proteins

P. C. Taylor, A. J. Clark, A. Marsh, D. R. J. Singer and S. J. Dilly, Chem. Commun., 2013, 49, 9588 DOI: 10.1039/C3CC44647F

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