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Issue 66, 2013
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Active ion transporters from readily accessible acyclic octapeptides containing 3-aminobenzoic acid and alanine

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Abstract

Ion transporters have been developed from acyclic octapeptides comprising L/D alanine and m-aminobenzoic acid. These octapeptides transport cations up to 3 times faster than their cyclic analog through lipid vesicles. Preliminary CD, XRD and computational studies allude to a 6–9 Å wide tetrameric ion channel as the active ion transporter.

Graphical abstract: Active ion transporters from readily accessible acyclic octapeptides containing 3-aminobenzoic acid and alanine

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The article was received on 05 Jun 2013, accepted on 24 Jun 2013 and first published on 24 Jun 2013


Article type: Communication
DOI: 10.1039/C3CC44224A
Citation: Chem. Commun., 2013,49, 7340-7342
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    Active ion transporters from readily accessible acyclic octapeptides containing 3-aminobenzoic acid and alanine

    B. P. Benke and N. Madhavan, Chem. Commun., 2013, 49, 7340
    DOI: 10.1039/C3CC44224A

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