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Issue 73, 2013
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[Gd(CyPic3A)(H2O)2]: a stable, bis(aquated) and high-relaxivity Gd(III) complex

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Abstract

We report the synthesis and MR relevant properties of CyPic3A, a heptadentate chelator that forms ternary Gd(III) complexes of hydration state q = 2. [Gd(CyPic3A)(H2O)2] affords an r1 value of 5.70 mM−1 s−1 at 1.41 T and 310 K and displays thermodynamic stability and kinetic inertness comparable to FDA approved MR imaging probes.

Graphical abstract: [Gd(CyPic3A)(H2O)2]−: a stable, bis(aquated) and high-relaxivity Gd(iii) complex

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Publication details

The article was received on 31 May 2013, accepted on 23 Jul 2013 and first published on 24 Jul 2013


Article type: Communication
DOI: 10.1039/C3CC44116D
Citation: Chem. Commun., 2013,49, 8060-8062
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    [Gd(CyPic3A)(H2O)2]: a stable, bis(aquated) and high-relaxivity Gd(III) complex

    E. M. Gale, N. Kenton and P. Caravan, Chem. Commun., 2013, 49, 8060
    DOI: 10.1039/C3CC44116D

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