Issue 68, 2013
From the journal:

Chemical Communications

Oxidative cross-coupling/cyclization to build polysubstituted pyrroles from terminal alkynes and β-enamino esters†

Jie Ke,‡a   Chuan He,‡a   Huiying Liu,a   Mengjun Lia  and  Aiwen Lei*ab  

* Corresponding authors

a College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, P. R. China
E-mail: aiwenlei@whu.edu.cn

b State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, 730000 Lanzhou, P. R. China

Abstract

A novel silver-mediated highly selective synthesis of polysubstituted pyrroles by the C–H/C–H oxidative cross-coupling/cyclization of terminal alkynes with β-enamino esters has been developed. This protocol represents a simple, efficient and selective way to construct polysubstituted pyrroles in good yields from basic chemical materials.

Graphical abstract: Oxidative cross-coupling/cyclization to build polysubstituted pyrroles from terminal alkynes and β-enamino esters

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Article information

DOI
https://doi.org/10.1039/C3CC43682A
Article type
Communication
Submitted
16 May 2013
Accepted
24 Jun 2013
First published
25 Jun 2013

Chem. Commun., 2013,49, 7549-7551

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Oxidative cross-coupling/cyclization to build polysubstituted pyrroles from terminal alkynes and β-enamino esters

J. Ke, C. He, H. Liu, M. Li and A. Lei, Chem. Commun., 2013, 49, 7549 DOI: 10.1039/C3CC43682A

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