Issue 77, 2013
From the journal:

Chemical Communications

Site-specific immobilization of biomolecules by a biocompatible reaction between terminal cysteine and 2-cyanobenzothiazole†

Ping Wang,‡a   Chong-Jing Zhang,‡b   Ganchao Chen,a   Zhenkun Na,b   Shao Q. Yaob  and  Hongyan Sun*ac  

* Corresponding authors

a Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, P. R. China
E-mail: hongysun@cityu.edu.hk
Fax: +852 3442 0522
Tel: +852 3442 9537

b Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543

c Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, P. R. China 518057

Abstract

We report herein a new site-specific microarray immobilization method based on a biocompatible reaction between terminal cysteine and 2-cyanobenzothiazole (CBT). This immobilization strategy has been successfully applied to anchor small molecules, peptides and proteins onto microarrays.

Graphical abstract: Site-specific immobilization of biomolecules by a biocompatible reaction between terminal cysteine and 2-cyanobenzothiazole

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Article information

DOI
https://doi.org/10.1039/C3CC43566K
Article type
Communication
Submitted
13 May 2013
Accepted
29 Jul 2013
First published
31 Jul 2013

Chem. Commun., 2013,49, 8644-8646

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Site-specific immobilization of biomolecules by a biocompatible reaction between terminal cysteine and 2-cyanobenzothiazole

P. Wang, C. Zhang, G. Chen, Z. Na, S. Q. Yao and H. Sun, Chem. Commun., 2013, 49, 8644 DOI: 10.1039/C3CC43566K

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