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Issue 66, 2013
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Gas-phase infrared spectrum and acidity of the radical cation of 9-methylguanine

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Abstract

Oxidative damage to DNA yields guanine radical cations. Their gas-phase IR spectroscopic signature and acidity have been modelled by the radical cation of 9-methylguanine. Comparisons with quantum chemistry calculations suggest that radical cation formation produces the ground-state keto tautomer, which has an N–H acidity enhanced by ∼470 kJ mol−1.

Graphical abstract: Gas-phase infrared spectrum and acidity of the radical cation of 9-methylguanine

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Publication details

The article was received on 02 May 2013, accepted on 03 Jul 2013 and first published on 15 Jul 2013


Article type: Communication
DOI: 10.1039/C3CC43244K
Citation: Chem. Commun., 2013,49, 7343-7345
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    Gas-phase infrared spectrum and acidity of the radical cation of 9-methylguanine

    L. Feketeová, G. N. Khairallah, B. Chan, V. Steinmetz, P. Maître, L. Radom and R. A. J. O'Hair, Chem. Commun., 2013, 49, 7343
    DOI: 10.1039/C3CC43244K

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