Issue 50, 2013

Thiol–ene click chemistry for the synthesis of highly effective glycosyl sulfonamide carbonic anhydrase inhibitors

Abstract

Thiol–ene click chemistry has been applied for obtaining sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitors incorporating sugar moieties. Most of these new compounds were moderate CA I inhibitors, effective CA II inhibitors, and low nanomolar/subnanomolar inhibitors of the tumor-associated isoforms CA IX and XII.

Graphical abstract: Thiol–ene click chemistry for the synthesis of highly effective glycosyl sulfonamide carbonic anhydrase inhibitors

Supplementary files

Article information

Article type
Communication
Submitted
08 Apr 2013
Accepted
30 Apr 2013
First published
30 Apr 2013

Chem. Commun., 2013,49, 5699-5701

Thiol–ene click chemistry for the synthesis of highly effective glycosyl sulfonamide carbonic anhydrase inhibitors

M. Saada, J. Ombouma, J. Montero, C. T. Supuran and J. Winum, Chem. Commun., 2013, 49, 5699 DOI: 10.1039/C3CC42541J

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