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Issue 85, 2013
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Synthesis and antitumor activity of a series of osmium(VI) nitrido complexes bearing quinolinolato ligands

Quan Tang,abc  Wen-Xiu Ni,b  Chi-Fai Leung,bd  Wai-Lun Man,b  Kenneth King-Kwan Lau,b  Yimin Liang,b  Yun-Wah Lam,b  Wai-Yeung Wong,e  Shie-Ming Peng,f  Gui-Jian Liu*ac  and  Tai-Chu Lau*ab 
Author affiliations

* Corresponding authors

a Advanced Laboratory of Environmental Research and Technology (ALERT), Joint Advanced Research Center, USTC-CityU, Hefei, China

b Department of Biology and Chemistry, City University of Hong Kong, and Institute of Molecular Functional Materials, Tat Chee Avenue, Kowloon Tong, China
E-mail: bhtclau@cityu.edu.hk
Fax: +852 34420522

c CAS Key Laboratory of Crust-Mantle Materials and the Environments, School of Earth and Space Sciences, University of Science and Technology of China, Hefei, China
E-mail: lgj@ustc.edu.cn

d Department of Science and Environmental Studies, The Hong Kong Institute of Education, 10 Lo Ping Road, Tai Po, New Territories, China

e Department of Chemistry, Hong Kong Baptist University, Waterloo Road, Kowloon Tong, China

f Department of Chemistry, National Taiwan University, Taipei 106, Republic of China

Abstract

A series of osmium(VI) nitrido complexes supported by quinolinolato ligands have been prepared and they exhibit promising in vitro anti-cancer activities. These results establish that OsVI[triple bond, length as m-dash]N is a potentially versatile and promising platform for the design of a variety of high-valent anti-cancer drugs.

Graphical abstract: Synthesis and antitumor activity of a series of osmium(vi) nitrido complexes bearing quinolinolato ligands

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Publication details

The article was received on 28 Mar 2013, accepted on 27 Aug 2013 and first published on 28 Aug 2013


Article type: Communication
DOI: 10.1039/C3CC42250J
Citation: Chem. Commun., 2013,49, 9980-9982
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    Synthesis and antitumor activity of a series of osmium(VI) nitrido complexes bearing quinolinolato ligands

    Q. Tang, W. Ni, C. Leung, W. Man, K. K. Lau, Y. Liang, Y. Lam, W. Wong, S. Peng, G. Liu and T. Lau, Chem. Commun., 2013, 49, 9980
    DOI: 10.1039/C3CC42250J

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