Jump to main content
Jump to site search

Issue 62, 2013
Previous Article Next Article

NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound

Author affiliations

Abstract

Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of 195Pt and 15N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange.

Graphical abstract: NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 22 Mar 2013, accepted on 07 May 2013 and first published on 09 May 2013


Article type: Communication
DOI: 10.1039/C3CC42098A
Citation: Chem. Commun., 2013,49, 6944-6946
  •   Request permissions

    NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound

    L. E. Wedlock, M. R. Kilburn, R. Liu, J. A. Shaw, S. J. Berners-Price and N. P. Farrell, Chem. Commun., 2013, 49, 6944
    DOI: 10.1039/C3CC42098A

Search articles by author