Jump to main content
Jump to site search

Issue 47, 2013
Previous Article Next Article

Cleavable trifunctional biotin reagents for protein labelling, capture and release

Author affiliations

Abstract

Trifunctional biotin reagents incorporating cleavable linkers are evaluated for their usage in protein enrichment. A linker based on the Dde protecting group leads to efficient release of protein targets under mild conditions. It additionally contains a masked trypsin cleavage site, which eliminates the majority of the tag during tryptic digestion.

Graphical abstract: Cleavable trifunctional biotin reagents for protein labelling, capture and release

Back to tab navigation

Supplementary files

Publication details

The article was received on 21 Mar 2013, accepted on 22 Apr 2013 and first published on 24 Apr 2013


Article type: Communication
DOI: 10.1039/C3CC42076K
Citation: Chem. Commun., 2013,49, 5366-5368
  •   Request permissions

    Cleavable trifunctional biotin reagents for protein labelling, capture and release

    Y. Yang and S. H. L. Verhelst, Chem. Commun., 2013, 49, 5366
    DOI: 10.1039/C3CC42076K

Search articles by author

Spotlight

Advertisements