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Issue 51, 2013
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A general strategy for obtaining biodegradable polymer shelled microbubbles as theranostic devices

Sabrina Capece,a  Ester Chiessi,a  Roberta Cavalli,b  Pierangela Giustetto,cd  Dmitry Grishenkove  and  Gaio Paradossi*a 
Author affiliations

* Corresponding authors

a Dipartimento di Scienze e Tecnologie Chimiche, Università di Roma Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
E-mail: paradossi@stc.uniroma2.it
Fax: +39 06 7259 4328
Tel: +39 06 7259 4464

b Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, Via P. Giuria 9, 10125 Torino, Italy

c University of Torino, Department of Molecular Biotechnology and Health Sciences, Molecular Imaging Center, Torino, Italy

d Center for Preclinical Imaging, Colleretto Giacosa, Italy

e Division of Medical Engineering, School of Technology and Health, Royal Institute of Technology, KTH, Alfred Nobels allé 10, SE-141 52 Huddinge, Sweden

Abstract

Fabrication of multifunctional ultrasound contrast agents (UCAs) has been recently addressed by several research groups. A versatile strategy for the synthesis of UCA precursors in the form of biodegradable vesicles with a biocompatible crosslinked polymer shell is described. Upon ultrasound irradiation, acoustic droplet vaporization transforms such particles into microbubbles behaving as UCAs. This proof of concept entails the features of a potential theranostic microdevice.

Graphical abstract: A general strategy for obtaining biodegradable polymer shelled microbubbles as theranostic devices

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Publication details

The article was received on 20 Mar 2013, accepted on 06 May 2013 and first published on 07 May 2013


Article type: Communication
DOI: 10.1039/C3CC42037J
Citation: Chem. Commun., 2013,49, 5763-5765
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    A general strategy for obtaining biodegradable polymer shelled microbubbles as theranostic devices

    S. Capece, E. Chiessi, R. Cavalli, P. Giustetto, D. Grishenkov and G. Paradossi, Chem. Commun., 2013, 49, 5763
    DOI: 10.1039/C3CC42037J

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