Issue 51, 2013
From the journal:

Chemical Communications

A synthetic approach to GFP chromophore analogs from 3-azidocinnamates. Role of methyl rotors in chromophore photophysics†

Mikhail S. Baranov,a   Kyril M. Solntsev,*b   Konstantin A. Lukyanova  and  Ilia V. Yampolsky*a  

* Corresponding authors

a Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia
E-mail: ivyamp@ibch.ru
Fax: +7 499-7428122
Tel: +7 499-7428122

b School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA 30332-0400, USA
E-mail: solntsev@gatech.edu
Fax: +1 404-894-7452
Tel: +1 404-385-3117

Abstract

We have suggested a novel combinatorial approach for synthesis of otherwise inaccessible GFP chromophore analogs, and studied the influence of aliphatic substituents on their pH-dependent spectral properties. We found that the demethylation at C or N positions of the imidazolone ring leads to a decrease in the excited state lifetime.

Graphical abstract: A synthetic approach to GFP chromophore analogs from 3-azidocinnamates. Role of methyl rotors in chromophore photophysics

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Article information

DOI
https://doi.org/10.1039/C3CC41948G
Article type
Communication
Submitted
15 Mar 2013
Accepted
03 May 2013
First published
03 May 2013

Chem. Commun., 2013,49, 5778-5780

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A synthetic approach to GFP chromophore analogs from 3-azidocinnamates. Role of methyl rotors in chromophore photophysics

M. S. Baranov, K. M. Solntsev, K. A. Lukyanov and I. V. Yampolsky, Chem. Commun., 2013, 49, 5778 DOI: 10.1039/C3CC41948G

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