Issue 27, 2013

Endonuclease IV discriminates mismatches next to the apurinic/apyrimidinic site in DNA strands: constructing DNA sensing platforms with extremely high selectivity

Abstract

A unique capability of Endonuclease IV in discrimination of mismatches neighboring a natural abasic site in DNA strands has been demonstrated, which enables genotyping of SNPs with high discrimination factors and differentiation of as low as 0.1–0.01% of target DNA strands from a large background of single-base different interfering strands.

Graphical abstract: Endonuclease IV discriminates mismatches next to the apurinic/apyrimidinic site in DNA strands: constructing DNA sensing platforms with extremely high selectivity

Supplementary files

Article information

Article type
Communication
Submitted
02 Feb 2013
Accepted
18 Feb 2013
First published
19 Feb 2013

Chem. Commun., 2013,49, 2819-2821

Endonuclease IV discriminates mismatches next to the apurinic/apyrimidinic site in DNA strands: constructing DNA sensing platforms with extremely high selectivity

X. Xiao, Y. Liu and M. Zhao, Chem. Commun., 2013, 49, 2819 DOI: 10.1039/C3CC40902C

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