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Issue 28, 2013
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Polymerization of a peptide-based enzyme substrate

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Abstract

Polymers of norbornenyl-modified peptide-based enzyme substrates have been prepared via ring-opening metathesis polymerization (ROMP). Peptides displayed on water-soluble homopolymers retain the ability to be enzymatically processed by a disease-associated enzyme. In contrast, when the peptides are densely arrayed on a nanoparticle derived from a self-assembled amphiphilic block-copolymer, they function with reduced activity as enzymatic substrates.

Graphical abstract: Polymerization of a peptide-based enzyme substrate

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Publication details

The article was received on 19 Jan 2013, accepted on 18 Feb 2013 and first published on 01 Mar 2013


Article type: Communication
DOI: 10.1039/C3CC40472B
Citation: Chem. Commun., 2013,49, 2873-2875
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    Polymerization of a peptide-based enzyme substrate

    M. E. Hahn, L. M. Randolph, L. Adamiak, M. P. Thompson and N. C. Gianneschi, Chem. Commun., 2013, 49, 2873
    DOI: 10.1039/C3CC40472B

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