Jump to main content
Jump to site search

Issue 19, 2013
Previous Article Next Article

The elusive crystal structure of the neuraminidase inhibitor Tamiflu (oseltamivir phosphate): molecular details of action

Author affiliations

Abstract

The first structure determination of a neuraminidase inhibitor, oseltamivir phosphate, the active component of the anti-influenza agent Tamiflu, was achieved by single crystal X-ray diffraction with synchrotron radiation. The structure reproduces to a great extent the binding of the inhibitor in the neuraminidase active site and provides more accurate structural parameters as well as detailed insight into the binding preferences of the inhibitor.

Graphical abstract: The elusive crystal structure of the neuraminidase inhibitor Tamiflu (oseltamivir phosphate): molecular details of action

Back to tab navigation

Supplementary files

Publication details

The article was received on 07 Dec 2012, accepted on 18 Jan 2013 and first published on 21 Jan 2013


Article type: Communication
DOI: 10.1039/C3CC38801H
Citation: Chem. Commun., 2013,49, 1948-1950
  •   Request permissions

    The elusive crystal structure of the neuraminidase inhibitor Tamiflu (oseltamivir phosphate): molecular details of action

    P. Naumov, N. Yasuda, W. M. Rabeh and J. Bernstein, Chem. Commun., 2013, 49, 1948
    DOI: 10.1039/C3CC38801H

Search articles by author

Spotlight

Advertisements