Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 19, 2013
Previous Article Next Article

Enantioselective total synthesis of virosaine A and bubbialidine

Author affiliations

Abstract

The first enantioselective total syntheses of virosaine A and bubbialidine are described. Key transformations include the formation of a tetracyclic intermediate via an intramolecular aza-Michael addition, generation of a N-hydroxy-pyrrolidine through a Cope elimination and an intramolecular [1,3]-dipolar cycloaddition to generate a complex 7-oxa-1-azabicyclo[3.2.1]octane ring system.

Graphical abstract: Enantioselective total synthesis of virosaine A and bubbialidine

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 07 Dec 2012, accepted on 17 Jan 2013 and first published on 18 Jan 2013


Article type: Communication
DOI: 10.1039/C3CC38783F
Citation: Chem. Commun., 2013,49, 1921-1923
  • Open access:
  •   Request permissions

    Enantioselective total synthesis of virosaine A and bubbialidine

    H. Miyatake-Ondozabal, L. M. Bannwart and K. Gademann, Chem. Commun., 2013, 49, 1921
    DOI: 10.1039/C3CC38783F

Search articles by author