Issue 26, 2013

Coupling biocatalysis and click chemistry: one-pot two-step convergent synthesis of enantioenriched 1,2,3-triazole-derived diols

Abstract

A fully convergent one-pot two-step synthesis of different chiral 1,2,3-triazole-derived diols in high yields and excellent enantio- and diastereoselectivities has been achieved under very mild conditions in aqueous medium by combining a single alcohol dehydrogenase (ADH) with a Cu-catalysed ‘click’ reaction.

Graphical abstract: Coupling biocatalysis and click chemistry: one-pot two-step convergent synthesis of enantioenriched 1,2,3-triazole-derived diols

Supplementary files

Article information

Article type
Communication
Submitted
03 Dec 2012
Accepted
07 Feb 2013
First published
08 Feb 2013

Chem. Commun., 2013,49, 2625-2627

Coupling biocatalysis and click chemistry: one-pot two-step convergent synthesis of enantioenriched 1,2,3-triazole-derived diols

A. Cuetos, F. R. Bisogno, I. Lavandera and V. Gotor, Chem. Commun., 2013, 49, 2625 DOI: 10.1039/C3CC38674K

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