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Issue 25, 2013
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Protein corona significantly reduces active targeting yield

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Abstract

When nanoparticles (NPs) are exposed to the biological environment, their surfaces become covered with proteins and biomolecules (e.g. lipids). Here, we report that this protein coating, or corona, reduces the targeting capability of surface engineered NPs by screening the active sites of the targeting ligands.

Graphical abstract: Protein corona significantly reduces active targeting yield

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Publication details

The article was received on 06 Oct 2012, accepted on 11 Feb 2013 and first published on 12 Feb 2013


Article type: Communication
DOI: 10.1039/C3CC37307J
Citation: Chem. Commun., 2013,49, 2557-2559
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    Protein corona significantly reduces active targeting yield

    V. Mirshafiee, M. Mahmoudi, K. Lou, J. Cheng and M. L. Kraft, Chem. Commun., 2013, 49, 2557
    DOI: 10.1039/C3CC37307J

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