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Issue 26, 2013
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Polyelectrolyte mediated intra and intermolecular crosslinking in microgel-based etalons for sensing protein concentration in solution

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Abstract

Biotin modified polycationic polymers are capable of penetrating the Au overlayer of poly(N-isopropylacrylamide)-co-acrylic acid microgel-based etalons. Once penetrated, the polycations crosslink the polyanionic microgels, causing them to collapse, resulting in a concomitant blue shift of the spectral peaks in the reflectance spectrum. We show that the magnitude of the blue shift depends on the concentration of the biotinylated polycation solution exposed to the etalon. This behavior is subsequently used for biosensing applications.

Graphical abstract: Polyelectrolyte mediated intra and intermolecular crosslinking in microgel-based etalons for sensing protein concentration in solution

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Publication details

The article was received on 10 Jan 2013, accepted on 15 Feb 2013 and first published on 25 Feb 2013


Article type: Communication
DOI: 10.1039/C3CC00211J
Citation: Chem. Commun., 2013,49, 2646-2648
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    Polyelectrolyte mediated intra and intermolecular crosslinking in microgel-based etalons for sensing protein concentration in solution

    M. R. Islam and M. J. Serpe, Chem. Commun., 2013, 49, 2646
    DOI: 10.1039/C3CC00211J

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