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Issue 12, 2013
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Photodegradation and inhibition of drug-resistant influenza virus neuraminidase using anthraquinonesialic acid hybrids

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Abstract

The anthraquinonesialic acid hybrids designed effectively degraded not only non-drug-resistant neuraminidase but also drug-resistant neuraminidase, which is an important target of anti-influenza therapy. Degradation was achieved using long-wavelength UV radiation in the absence of any additives and under neutral conditions. Moreover, the hybrids efficiently inhibited neuraminidase activities upon photo-irradiation.

Graphical abstract: Photodegradation and inhibition of drug-resistant influenza virus neuraminidase using anthraquinone–sialic acid hybrids

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Publication details

The article was received on 12 Nov 2012, accepted on 17 Dec 2012 and first published on 18 Dec 2012


Article type: Communication
DOI: 10.1039/C2CC38742E
Citation: Chem. Commun., 2013,49, 1169-1171
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    Photodegradation and inhibition of drug-resistant influenza virus neuraminidase using anthraquinonesialic acid hybrids

    Y. Aoki, S. Tanimoto, D. Takahashi and K. Toshima, Chem. Commun., 2013, 49, 1169
    DOI: 10.1039/C2CC38742E

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