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Issue 9, 2013
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Phosphonite mediated 1,3-dipolar cycloaddition: a route to polycyclic 2-pyrrolines from imines, acid chlorides and alkenes

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Abstract

2-Pyrrolines can be generated by the PhP(2-catechyl) mediated coupling of alkene-tethered imines and acid chlorides. This reaction proceeds via phosphorus-containing 1,3-dipoles, which undergo cycloaddition with alkenes with high stereo- and regioselectivity. The modularity of this reaction can be used to assemble a range of polysubstituted pyrrolines in one pot transformations.

Graphical abstract: Phosphonite mediated 1,3-dipolar cycloaddition: a route to polycyclic 2-pyrrolines from imines, acid chlorides and alkenes

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Publication details

The article was received on 16 Nov 2012, accepted on 05 Dec 2012 and first published on 06 Dec 2012


Article type: Communication
DOI: 10.1039/C2CC38274A
Citation: Chem. Commun., 2013,49, 883-885
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    Phosphonite mediated 1,3-dipolar cycloaddition: a route to polycyclic 2-pyrrolines from imines, acid chlorides and alkenes

    M. S. T. Morin, S. Aly and B. A. Arndtsen, Chem. Commun., 2013, 49, 883
    DOI: 10.1039/C2CC38274A

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