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Issue 12, 2013
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DNA nanostructure serum stability: greater than the sum of its parts

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Abstract

Simple chemical modifications to oligonucleotide ends with hexaethylene glycol and hexanediol are shown to significantly increase nuclease resistance under serum conditions. The modified oligonucleotides were used to construct DNA prismatic cages in a single step and in quantitative yield. These cages further stabilize their strands towards nucleases, with lifetimes of 62 hours in serum. The cages contain a large number of single-stranded regions for functionalization, illustrating their versatility for biological applications.

Graphical abstract: DNA nanostructure serum stability: greater than the sum of its parts

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Publication details

The article was received on 17 Oct 2012, accepted on 12 Dec 2012 and first published on 19 Dec 2012


Article type: Communication
DOI: 10.1039/C2CC37556G
Citation: Chem. Commun., 2013,49, 1172-1174
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    DNA nanostructure serum stability: greater than the sum of its parts

    J. W. Conway, C. K. McLaughlin, K. J. Castor and H. Sleiman, Chem. Commun., 2013, 49, 1172
    DOI: 10.1039/C2CC37556G

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