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Issue 26, 2013
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A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders

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Abstract

Metal-ion misregulation and oxidative stress have been linked to the progressive neurological decline associated with multiple neurodegenerative disorders. Transition metal-mediated oxidation of biomolecules via Fenton chemical reactions plays a role in disease progression. Herein we report the synthesis, characterization and antioxidant activity of 2; a pyclen derivative with enhanced antioxidant character.

Graphical abstract: A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders

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Publication details

The article was received on 31 Aug 2012, accepted on 17 Dec 2012 and first published on 25 Feb 2013


Article type: Communication
DOI: 10.1039/C2CC36808K
Citation: Chem. Commun., 2013,49, 2712-2714
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    A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders

    K. M. Lincoln, P. Gonzalez, T. E. Richardson, D. A. Julovich, R. Saunders, J. W. Simpkins and K. N. Green, Chem. Commun., 2013, 49, 2712
    DOI: 10.1039/C2CC36808K

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