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Issue 17, 2014
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Efficient synthesis of chiral cyclic acetals by metal and Brønsted acid co-catalyzed enantioselective four-component cascade reactions

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Abstract

Four-component Mannich reactions subsequently followed by an intramolecular oxo-Michael addition were developed to efficiently produce chiral cyclic acetals with high diastereoselectivity and enantioselectivity.

Graphical abstract: Efficient synthesis of chiral cyclic acetals by metal and Brønsted acid co-catalyzed enantioselective four-component cascade reactions

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Publication details

The article was received on 27 Nov 2013, accepted on 20 Dec 2013 and first published on 23 Dec 2013


Article type: Communication
DOI: 10.1039/C3CC49063G
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2014,50, 2196-2198
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    Efficient synthesis of chiral cyclic acetals by metal and Brønsted acid co-catalyzed enantioselective four-component cascade reactions

    L. Qiu, X. Guo, C. Ma, H. Qiu, S. Liu, L. Yang and W. Hu, Chem. Commun., 2014, 50, 2196
    DOI: 10.1039/C3CC49063G

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