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Issue 30, 2014
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Amino acid-linked platinum(II) analogues have altered specificity for RNA compared to cisplatin

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Abstract

Cisplatin can be modified with various ligands to alter the size and charge distribution of the complex. Several amino acid-linked platinum(II) complexes were synthesized, and a reactivity study with 16S ribosomal RNA was carried out. The amino acid-linked analogues show altered specificity compared to the parental compound cisplatin.

Graphical abstract: Amino acid-linked platinum(ii) analogues have altered specificity for RNA compared to cisplatin

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Publication details

The article was received on 27 Nov 2013, accepted on 18 Dec 2013 and first published on 19 Dec 2013


Article type: Communication
DOI: 10.1039/C3CC49035A
Citation: Chem. Commun., 2014,50, 3918-3920
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    Amino acid-linked platinum(II) analogues have altered specificity for RNA compared to cisplatin

    K. Rijal, X. Bao and C. S. Chow, Chem. Commun., 2014, 50, 3918
    DOI: 10.1039/C3CC49035A

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