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Issue 28, 2014
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Salt as a catalyst in the mitochondria: returning cytochrome c to its native state after it misfolds on the surface of cardiolipin containing membranes

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Abstract

Cytochrome c binding to cardiolipin receptors on the surface of TOCL/DOPC(20% : 80%) liposomes induces a conformational change, which is not reversible after the protein's dissociation at low ionic strength. Addition of 100 mM NaCl switches the protein back to its native state.

Graphical abstract: Salt as a catalyst in the mitochondria: returning cytochrome c to its native state after it misfolds on the surface of cardiolipin containing membranes

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Publication details

The article was received on 14 Nov 2013, accepted on 05 Dec 2013 and first published on 05 Dec 2013


Article type: Communication
DOI: 10.1039/C3CC48709A
Citation: Chem. Commun., 2014,50, 3674-3676
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    Salt as a catalyst in the mitochondria: returning cytochrome c to its native state after it misfolds on the surface of cardiolipin containing membranes

    L. A. Pandiscia and R. Schweitzer-Stenner, Chem. Commun., 2014, 50, 3674
    DOI: 10.1039/C3CC48709A

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