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Issue 24, 2014
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The nitrilimine–alkene cycloaddition is an ultra rapid click reaction

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Abstract

The transient formation of nitrilimine in aqueous conditions is greatly influenced by pH and chloride. In basic conditions (pH 10) with no chloride, a diarylnitrilimine precursor readily ionizes to form diarylnitrilimine that reacts almost instantly with an acrylamide-containing protein and fluorescently labels it.

Graphical abstract: The nitrilimine–alkene cycloaddition is an ultra rapid click reaction

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Publication details

The article was received on 14 Nov 2013, accepted on 19 Dec 2013 and first published on 20 Dec 2013


Article type: Communication
DOI: 10.1039/C3CC48682F
Citation: Chem. Commun., 2014,50, 3176-3179
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    The nitrilimine–alkene cycloaddition is an ultra rapid click reaction

    X. S. Wang, Y. Lee and W. R. Liu, Chem. Commun., 2014, 50, 3176
    DOI: 10.1039/C3CC48682F

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