Jump to main content
Jump to site search

Issue 10, 2014
Previous Article Next Article

Solution-phase-peptide synthesis via the group-assisted purification (GAP) chemistry without using chromatography and recrystallization

Author affiliations

Abstract

The solution phase synthesis of N-protected amino acids and peptides has been achieved through the Group-Assisted Purification (GAP) chemistry by avoiding disadvantages of other methods in regard to the difficult scale-up, expenses of solid and soluble polymers, etc. The GAP synthesis can reduce the use of solvents, silica gels, energy and manpower. In addition, the GAP auxiliary can be conveniently recovered for re-use and is environmentally friendly and benign, and substantially reduces waste production in academic labs and industry.

Graphical abstract: Solution-phase-peptide synthesis via the group-assisted purification (GAP) chemistry without using chromatography and recrystallization

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 07 Nov 2013, accepted on 26 Nov 2013 and first published on 27 Nov 2013


Article type: Communication
DOI: 10.1039/C3CC48509A
Citation: Chem. Commun., 2014,50, 1259-1261
  •   Request permissions

    Solution-phase-peptide synthesis via the group-assisted purification (GAP) chemistry without using chromatography and recrystallization

    J. Wu, G. An, S. Lin, J. Xie, W. Zhou, H. Sun, Y. Pan and G. Li, Chem. Commun., 2014, 50, 1259
    DOI: 10.1039/C3CC48509A

Search articles by author