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Issue 10, 2014
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Asymmetric synthesis of N-stereogenic molecules: diastereoselective double aza-Michael reaction

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Abstract

A novel approach towards the asymmetric synthesis of N-stereogenic molecules via double aza-Michael addition was developed. The diastereomeric ratio can be increased by a thermodynamically controlled isomerization mechanism. Simple separation and functionalization of the products afford N-stereogenic compounds in high enantiomeric purity.

Graphical abstract: Asymmetric synthesis of N-stereogenic molecules: diastereoselective double aza-Michael reaction

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Publication details

The article was received on 06 Nov 2013, accepted on 19 Nov 2013 and first published on 21 Nov 2013


Article type: Communication
DOI: 10.1039/C3CC48486F
Citation: Chem. Commun., 2014,50, 1195-1197
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    Asymmetric synthesis of N-stereogenic molecules: diastereoselective double aza-Michael reaction

    A. Lauber, B. Zelenay and J. Cvengroš, Chem. Commun., 2014, 50, 1195
    DOI: 10.1039/C3CC48486F

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