Issue 8, 2014
From the journal:

Chemical Communications

Antibody-mediated functional control of a dansylated polytheonamide mimic†

Hiroaki Itoha  and  Masayuki Inoue*a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
E-mail: inoue@mol.f.u-tokyo.ac.jp
Fax: +81 3-5841-0568

Abstract

We demonstrate the functional control of a dansylated polytheonamide mimic (2), an artificial ion channel-forming cytotoxic peptide, by the external addition of a polyclonal anti-dansyl antibody (anti-dansyl IgG). The IgG effectively suppressed the ion transport activity and cytotoxicity of 2 in a dose-dependent manner.

Graphical abstract: Antibody-mediated functional control of a dansylated polytheonamide mimic

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Article information

DOI
https://doi.org/10.1039/C3CC48348G
Article type
Communication
Submitted
31 Oct 2013
Accepted
18 Nov 2013
First published
18 Nov 2013

Chem. Commun., 2014,50, 939-941

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Antibody-mediated functional control of a dansylated polytheonamide mimic

H. Itoh and M. Inoue, Chem. Commun., 2014, 50, 939 DOI: 10.1039/C3CC48348G

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