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Issue 13, 2014
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Highly emissive deoxyguanosine analogue capable of direct visualization of B–Z transition

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Abstract

A 2-aminothieno[3,4-d]pyrimidine G-mimic deoxyribonucleoside, thdG, was synthesized and incorporated readily into oligonucleotides as a versatile fluorescent guanine analogue. We demonstrate that thdG enables the visual detection of Z-DNA successfully based on different π-stacking of B- and Z-DNA.

Graphical abstract: Highly emissive deoxyguanosine analogue capable of direct visualization of B–Z transition

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Publication details

The article was received on 30 Oct 2013, accepted on 04 Dec 2013 and first published on 05 Dec 2013


Article type: Communication
DOI: 10.1039/C3CC48297A
Citation: Chem. Commun., 2014,50, 1573-1575
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    Highly emissive deoxyguanosine analogue capable of direct visualization of B–Z transition

    S. Park, H. Otomo, L. Zheng and H. Sugiyama, Chem. Commun., 2014, 50, 1573
    DOI: 10.1039/C3CC48297A

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