Issue 13, 2014

Highly emissive deoxyguanosine analogue capable of direct visualization of B–Z transition

Abstract

A 2-aminothieno[3,4-d]pyrimidine G-mimic deoxyribonucleoside, thdG, was synthesized and incorporated readily into oligonucleotides as a versatile fluorescent guanine analogue. We demonstrate that thdG enables the visual detection of Z-DNA successfully based on different π-stacking of B- and Z-DNA.

Graphical abstract: Highly emissive deoxyguanosine analogue capable of direct visualization of B–Z transition

Supplementary files

Article information

Article type
Communication
Submitted
30 Oct 2013
Accepted
04 Dec 2013
First published
05 Dec 2013

Chem. Commun., 2014,50, 1573-1575

Highly emissive deoxyguanosine analogue capable of direct visualization of B–Z transition

S. Park, H. Otomo, L. Zheng and H. Sugiyama, Chem. Commun., 2014, 50, 1573 DOI: 10.1039/C3CC48297A

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