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Issue 12, 2014
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Ultrasensitive detection of thrombin using surface plasmon resonance and quartz crystal microbalance sensors by aptamer-based rolling circle amplification and nanoparticle signal enhancement

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Abstract

The surface plasmon resonance (SPR) and quartz crystal microbalance (QCM) aptasensors combined with rolling circle amplification and bio-bar-coded AuNP enhancement have been applied to detect the human α-thrombin for the first time. The assay platform exhibited excellent selectivity and sensitivity with detection limit as low as 0.78 aM.

Graphical abstract: Ultrasensitive detection of thrombin using surface plasmon resonance and quartz crystal microbalance sensors by aptamer-based rolling circle amplification and nanoparticle signal enhancement

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Publication details

The article was received on 27 Oct 2013, accepted on 27 Nov 2013 and first published on 28 Nov 2013


Article type: Communication
DOI: 10.1039/C3CC48223E
Citation: Chem. Commun., 2014,50, 1481-1484
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    Ultrasensitive detection of thrombin using surface plasmon resonance and quartz crystal microbalance sensors by aptamer-based rolling circle amplification and nanoparticle signal enhancement

    P. He, L. Liu, W. Qiao and S. Zhang, Chem. Commun., 2014, 50, 1481
    DOI: 10.1039/C3CC48223E

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