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Issue 10, 2014
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The synthesis and structure revision of NSC-134754

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Abstract

The synthesis of emetine analogue NSC-134754, a potent inhibitor of the HIF pathway, has been accomplished and its structure reassigned. The stereochemistry of NSC-134754 has been assigned for the first time using X-ray crystallography and it has been demonstrated that only one diastereoisomer is active against HIF.

Graphical abstract: The synthesis and structure revision of NSC-134754

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Publication details

The article was received on 28 Oct 2013, accepted on 05 Dec 2013 and first published on 09 Dec 2013


Article type: Communication
DOI: 10.1039/C3CC48189A
Citation: Chem. Commun., 2014,50, 1238-1240
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    The synthesis and structure revision of NSC-134754

    J. A. Hickin, A. Ahmed, K. Fucke, M. Ashcroft and K. Jones, Chem. Commun., 2014, 50, 1238
    DOI: 10.1039/C3CC48189A

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