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Issue 10, 2014
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Applications of pentafluorophenyl boron reagents in the synthesis of heterocyclic and aromatic compounds

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Abstract

Recently, main group reagents have attracted a lot of attention in bond-forming reactions in organic synthesis. This article highlights the use of pentafluorophenyl substituted boron reagents in their reactions with C[double bond, length as m-dash]C and C[triple bond, length as m-dash]C π-bonds for the synthesis of heterocyclic and aromatic compounds. These cyclisation reactions fall into four general classes although there is some overlap between classes and often combinations of these different types of reactivity are observed in the formation of the final heterocyclic product: (i) 1,2- (and 1,4-) additions of nucleophile and Lewis-acidic boron centre, (ii) 1,1-carboboration, (iii) carbocation rearrangements and (iv) cycloaddition chemistry. In addition, the prospect of using such boron reagents catalytically in the synthesis of aromatic compounds such as oxazoles and dibenzopentalene derivatives is emphasised.

Graphical abstract: Applications of pentafluorophenyl boron reagents in the synthesis of heterocyclic and aromatic compounds

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Publication details

The article was received on 18 Oct 2013, accepted on 21 Nov 2013 and first published on 22 Nov 2013


Article type: Feature Article
DOI: 10.1039/C3CC48036D
Citation: Chem. Commun., 2014,50, 1161-1174
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    Applications of pentafluorophenyl boron reagents in the synthesis of heterocyclic and aromatic compounds

    R. L. Melen, Chem. Commun., 2014, 50, 1161
    DOI: 10.1039/C3CC48036D

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