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Issue 12, 2014
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A copper-mediated tandem reaction through isocyanide insertion into N–H bonds: efficient access to unsymmetrical tetrasubstituted ureas

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Abstract

A copper-mediated multi-component reaction was developed through isocyanide insertion into N–H bonds of less active secondary arylamines. This approach leads to an efficient synthesis of unsymmetrical tetrasubstituted ureas in one pot.

Graphical abstract: A copper-mediated tandem reaction through isocyanide insertion into N–H bonds: efficient access to unsymmetrical tetrasubstituted ureas

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Publication details

The article was received on 03 Oct 2013, accepted on 26 Nov 2013 and first published on 27 Nov 2013


Article type: Communication
DOI: 10.1039/C3CC47590E
Citation: Chem. Commun., 2014,50, 1465-1468
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    A copper-mediated tandem reaction through isocyanide insertion into N–H bonds: efficient access to unsymmetrical tetrasubstituted ureas

    X. Huang, S. Xu, Q. Tan, M. Gao, M. Li and B. Xu, Chem. Commun., 2014, 50, 1465
    DOI: 10.1039/C3CC47590E

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