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Issue 10, 2014
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A library screening approach identifies naturally occurring RNA sequences for a G-quadruplex binding ligand

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Abstract

An RNA G-quadruplex library was synthesised and screened against kanamycin A as the ligand. Naturally occurring G-quadruplex forming sequences that differentially bind to kanamycin A were identified and characterized. This provides a simple and effective strategy for identification of potential intracellular G-quadruplex targets for a ligand.

Graphical abstract: A library screening approach identifies naturally occurring RNA sequences for a G-quadruplex binding ligand

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Publication details

The article was received on 26 Sep 2013, accepted on 25 Nov 2013 and first published on 25 Nov 2013


Article type: Communication
DOI: 10.1039/C3CC47381C
Citation: Chem. Commun., 2014,50, 1250-1252
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    A library screening approach identifies naturally occurring RNA sequences for a G-quadruplex binding ligand

    G. Mirihana Arachchilage, M. J. Morris and S. Basu, Chem. Commun., 2014, 50, 1250
    DOI: 10.1039/C3CC47381C

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